Denson G. Fujikawa 2+ within the early Eighties it used to be well-known that over the top Ca inflow, most likely via 2+ 2+ voltage-gated Ca channels, with a resultant elevate in intracellular Ca, used to be linked to neuronal demise from cerebral ischemia, hypoglycemia, and standing epilepticus (Siejo 1981). Calcium activation of phospholipases, with arachidonic acid accumulation and its oxidation, producing unfastened radicals, used to be considered a possible mechanism through which neuronal harm happens. In cerebral ischemia and a couple of+ hypoglycemia, strength failure was once regarded as the cause of over the top Ca inflow, while in prestige epilepticus it was once proposal that repetitive depolarizations have been in charge (Siejo 1981). in the meantime, John Olney came upon that monosodium glutamate, the foodstuff additive, while given to immature rats, used to be linked to neuronal degeneration within the arcuate nucleus of the hypothalamus, which lacks a blood-brain barrier (Olney 1969). He up this statement with a sequence of observations within the Nineteen Seventies that management of kainic acid, which we now comprehend prompts the GluR5-7 subtypes of glutamate receptor, and different glutamate analogues, triggered not just post-synaptic cytoplasmic swelling, but additionally dark-cell degeneration of neurons, whilst seen through electron microscopy (Olney 1971; Olney et al. 1974).
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Extra info for Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms
5 months. Many other women have a contraindication to HRT, such as a history of an estrogen-sensitive tumor, liver dysfunction, or a hypercoagulable state. Safe, effective, and well-tolerated alternative therapies for hot flashes are needed. Gabapentin is a gamma-aminobutyric acid (GABA)-analog approved in 1994 for the treatment of seizures. Since then, it has been shown that gabapentin is efficacious for numerous off-label indications such as neuropathic pain, anxiety, bipolar disorder, and migraine headaches.
The studies are: Project #1 (Dr. Karen Prestwood) The effect of therapeutic touch on bone metabolism in postmenopausal women after wrist fracture; Project #2 (Dr. Gloria Gronowicz) The effect of therapeutic touch on bone formation in vitro; Project #3 (Dr. Theresa Smith) The effect of therapeutic touch on human fibroblast biology; and Project #4 (Dr. Susan Lutgendorf) Healing touch in advanced cervical cancer: immune effects and mechanisms. Generate_Screen • Project Title: GABAPENTIN VS ESTROGEN FOR THE TREATMENT OF HOT FLUSHES Principal Investigator & Institution: Reddy, Sireesha; Obstetrics and Gynecology; University of Rochester Orpa - Rc Box 270140 Rochester, Ny 14627 Timing: Fiscal Year 2003; Project Start 01-MAY-2003; Project End 30-APR-2005 Summary: (provided by applicant): Hot flashes and other climacteric symptoms affect 75% of postmenopausal women in the US and are associated with higher rates of depression and sleep disturbance.
Utilizing an anesthetized rat model, we now propose to obtain a pharmacodynamic profile of DS1. We will simultaneously compare the regional blood flow and the mean peripheral arterial pressure in order to verify regional selectivity. Justification of further development towards commercialization will require 1) no decrease in systemic blood pressure, 2) >100 percent increase in vaginal blood flow, and 3) duration of regional hyperemia >30 minutes. ; Research Professor; Rhode Island Hospital (Providence, Ri) Providence, Ri 02903 Timing: Fiscal Year 2001; Project Start 01-APR-1988; Project End 31-JUL-2004 Summary: (Adapted from the Investigator's Abstract): The trigeminal nerve mediates pain sensation from craniofacial tissues including specialized structures such as the teeth, dura, and cornea.
Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms