Download PDF by Hiroshi Mitsumoto MD: Amyotrophic Lateral Sclerosis

By Hiroshi Mitsumoto MD

ISBN-10: 0803602693

ISBN-13: 9780803602694

ISBN-10: 1423763467

ISBN-13: 9781423763468

Amyotrophic Lateral Sclerosis provides the main accomplished, clinically-focused info on ALS (Lou Gehrig's disorder) in print. the 3 authors, widely recognized for his or her paintings during this sector, offer cohesive and balanced insurance of this syndrome, together with the background, scientific beneficial properties, pathology and pathogenesis, therapy and administration of ALS. To facilitate figuring out, every one bankruptcy is more desirable by way of entire tables and figures, in addition to particular bankruptcy summaries.

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Sample text

In 1959, Engel and colleagues21 first recognized posterior column involvement in familial ALS. In 1967, Hirano and colleagues33 further characterized the pathologic features of familial ALS (see Chapter 11). Extensive epidemiologic studies per39 formed by Kurland and Mulder in 1955 es- tablished the frequency of familial ALS at 5% to 10%. In 1976, Horton and colleagues35 recognized the variability among familial ALS cases and attempted to classify reported cases of familial ALS in three categories based on length of the disease and pathologic features.

In 1860, Bernard Luys,42 who described the corpus Luysii, reported ventral horn cell degeneration in PMA. In the same year, Duchenne18 made an unsurpassed description of progressive bulbar palsy (PBP) and distinguished it from PMA by the degree and rapidity of bulbar involvement, but he also reported that one of his patients had both diseases. Charcot's Contribution In 1869, Jean Martin Charcot,14 the first professor of neurology at the Salpetriere, and Joffroy described two cases of PMA with lesions in the posterolateral spinal cord.

Neurology 4:355-378 (part 1), 438-448 (part 2), 1954. 39. Kurland, LT and Mulder, DW: Epidemiologic investigations of amyotrophic lateral sclerosis. Familial aggregation indicative of dominant inheritance. Neurology 5:182-196, 1955. 40. Lawyer, JR, Netsky, T, and Netsky, MG: Amyotrophic lateral sclerosis. Arch Neurol Psychiatry 69:171-192, 1953. 41. Leyden, EV: Uber progressive Bulbarparalysie. Arch Psychiatr i:648; ii:657; iii:338, 1870. 42. Luys, J: Atrophie musculaire progressive. Gaz Med Fr 3 & 4: 505, 1860.

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Amyotrophic Lateral Sclerosis by Hiroshi Mitsumoto MD


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